Table 7.
ADR incidence in different categories of TB patients with and without DM.
| ADRs | Category I (n = 255) | Category II (n = 61) | |||||
|---|---|---|---|---|---|---|---|
| TB with DM (n = 41) | TB without DM (n = 214) | p value1 | TB with DM (n = 09) | TB without DM (n = 52) | p value2 | p value3 | |
| ADR incidence, n (%) | ADR incidence, n (%) | ADR incidence, n (%) | ADR incidence, n (%) | ||||
| Nausea and vomiting | 11 (26.8) | 38 (17.7) | 0.177 | 02 (22.2) | 12 (23.07) | 0.955 | 0.775 |
| Rashes | 10 (24.4) | 43 (20.1) | 0.534 | 02 (22.2) | 19 (36.5) | 0.404 | 0.890 |
| Peripheral neuropathy | 14 (34.1) | 45 (21.0) | 0.068 | 04 (44.4) | 17 (32.7) | 0.493 | 0.560 |
| Liver injury | 07 (17.1) | 32 (15.0) | 0.730 | 04 (44.4) | 16 (30.8) | 0.420 | 0.073 |
| Restlessness | 15 (36.6) | 36 (16.8) | 0.004∗ | 06 (66.6) | 12 (23.1) | 0.008∗ | 0.098 |
| GI problem | 05 (12.2) | 18 (8.4) | 0.438 | 02 (22.2) | 05 (9.6) | 0.273 | 0.432 |
| Hypoglycemia | 01 (2.4) | 00 | 0.022∗ | 01 (11.1) | 00 | 0.015∗ | 0.229 |
| Joint pain | 05 (12.2) | 19 (8.9) | 0.505 | 02 (22.2) | 13 (25.0) | 0.858 | 0.432 |
| Drowsiness | 05 (12.2) | 31 (14.5) | 0.700 | 00 | 10 (19.2) | 0.150 | 0.269 |
| Back pain | 05 (12.2) | 07 (3.3) | 0.013∗ | 02 (22.2) | 02 (3.9) | 0.040∗ | 0.432 |
| Feet pain | 04 (9.7) | 06 (2.8) | 0.036∗ | 01 (11.1) | 00 | 0.015∗ | 0.902 |
| Body ache | 04 (9.7) | 07 (3.3) | 0.061 | 01 (11.1) | 04 (7.7) | 0.730 | 0.902 |
| Blurring vision | 01 (2.4) | 03 (1.4) | 0.624 | 00 | 00 | 00 | 0.636 |
| Other nervous system disorders | 16 (39.0) | 52 (24.3) | 0.051 | 04 (44.4) | 22 (42.3) | 0.905 | 0.764 |
1Data compared between TB with DM and TB without DM group in category I patients.
2Data compared between TB with DM and TB without DM group in category II patients.
3Data compared between TB with DM patients between category I and category II patients.
ADR: adverse drug reaction; TB: tuberculosis; DM: diabetes mellitus; all data has been analyzed by chi square test; ∗ p ≤ 0.05 was considered as significant.