Table 1.
Prospective risk of stillbirth and risk of neonatal death in weekly intervals in uncomplicated dichorionic and monochorionic twin pregnancies from 34 weeks’ gestation
| Gestational age (weeks) | No of stillbirths/No of ongoing pregnancies | Crude risk of stillbirth (per 1000 pregnancies) (95% CI) | No of neonatal deaths/No of women delivered | Risk of neonatal death* (per 1000 pregnancies) (95% CI) | Pooled risk difference† (per 1000 pregnancies) (95% CI) |
|---|---|---|---|---|---|
| Dichorionic twin pregnancies (15 studies) | |||||
| 34+0-6 | 21/17 830 | 1.2 (0.7 to 1.8) | 12/1742 | 6.7 (3.3 to 13.5) | −5.8 (−10.4 to −1.2) |
| 35+0-6 | 12/15 470 | 0.8 (0.4 to 1.4) | 15/2611 | 4.6 (2.4 to 8.7) | −5.1 (−8.7 to −1.6) |
| 36+0-6 | 18/11 824 | 1.5 (0.9 to 2.4) | 12/4238 | 3.2 (1.7 to 5.9) | −1.3 (−3.6 to 0.9) |
| 37+0-6 | 23/6824 | 3.4 (2.1 to 5.1) | 10/5141 | 2.2 (1.1 to 4.3) | 1.2 (−1.3 to 3.6) |
| 38+0-6 | 28/2633 | 10.6 (7.1 to 15.3) | 5/2581 | 1.5 (0.7 to 3.3) | 8.8 (3.6 to 14.0) |
| 39+0-6 | 7/752 | 9.3 (3.8 to 19.1) | 3/751 | 1.1 (0.4 to 2.6) | 3.8 (−8.5 to 16.1) |
| Monochorionic twin pregnancies (13 studies) | |||||
| 34+0-6 | 2/2149 | 0.9 (0.1 to 3.4) | 4/247 | 12.1 (4.2 to 34.3) | −15.6 (−40.4 to 9.1) |
| 35+0-6 | 5/1797 | 2.8 (0.9 to 6.5) | 2/367 | 8.1 (3.4 to 19.3) | −2.4 (−17.6 to 12.8) |
| 36+0-6 | 6/1325 | 4.5 (1.7 to 9.8) | 3/534 | 5.4 (2.2 to 13.3) | −1.5 (−14.4 to 11.4) |
| 37+0-6 | 7/730 | 9.6 (3.9 to 19.7) | 4/532 | 3.6 (1.2 to 11.1) | 2.5 (−12.4 to 17.4) |
| 38+0-6 | 2/264 | 7.6 (0.9 to 27.1) | 0/307 | 2.4 (0.6 to 10.3) | 7.0 (−19.7 to 33.7) |
*Risk of neonatal death computed by multilevel logistic regression model (see text).
†Individual studies risk differences pooled by fixed effect model meta-analysis (see text).