Table 1. Comparison of the abundance of proteins differentially expressed in HVs and CKD/CVD patients.
| Protein names | ID | ANOVA p | CKD1-2/HV | CKD3-4/HV | CKD5/HV | CVDI/HV | CVDII/HV |
|---|---|---|---|---|---|---|---|
| Adiponectin | Q15848 | 0.00316 | 1.69* | 1.34 | 2.05* | 0.65* | 0.39* |
| Angiogenin | P03950 | 2.07E-15 | 8.56** | 13.40*** | 33.90*** | 6.39* | 3.85* |
| Angiotensinogen | P01019 | 1.90E-06 | 1.06 | 0.65*** | 0.86 | 0.46** | 0.45*** |
| Antigen CD14 | P08571 | 0.00033 | 2.03* | 2.85** | 3.68*** | 1.51* | 1.59* |
| Apo A-I | P02647 | 1.03E-06 | 1.14 | 0.53** | 0.49* | 0.31* | 0.36*** |
| Apo A-II | P02652 | 0.00583 | 1.01 | 0.54* | 0.54* | 0.53** | 0.58** |
| Apo A-IV | P06727 | 3.79E-31 | 1.55* | 2.16*** | 3.09*** | 0.46*** | 0.61*** |
| Apo B-100 | P04114 | 0.00167 | 1.45*** | 1.55* | 1.68* | 1.11 | 1 |
| Apo C-I | P02654 | 0.01084 | 1.39* | 1.06 | 1.59* | 0.87 | 0.73 |
| Apo C-II | P02655 | 0.04411 | 1.46* | 1.59*** | 1.40** | 1.44 | 1.46** |
| Apo C-III | P02656 | 0.00099 | 1.33 | 1.59** | 1.62*** | 1.02 | 1.04 |
| Apo E | P02649 | 5.25E-05 | 1.27* | 0.88 | 1.12 | 0.41* | 0.49* |
| Apo F | Q13790 | 0.00938 | 1.56* | 2.07*** | 1.79** | 1.55* | 1.58* |
| Apo H | P02749 | 3.10E-07 | 1.21* | 1.54*** | 1.64*** | 1.26* | 1.15 |
| Apo L1 | O14791 | 0.04986 | 1.50* | 1.03 | 0.98 | 1.09 | 0.97 |
| Apo M | O95445 | 0.00917 | 0.89* | 0.78** | 0.83* | 0.50** | 0.55** |
| Cholinesterase | P06276 | 0.00152 | 1.85* | 0.81 | 0.66* | 0.82 | 0.39* |
| Fibrinogen α | P02671 | 1.65E-13 | 1.50*** | 1.56*** | 1.71*** | 1.55* | 1.52** |
| Fibrinogen β | P02675 | 1.43E-12 | 1.73*** | 2.01*** | 2.06*** | 1.50* | 1.65*** |
| Fibrinogen γ | P02679 | 1.07E-10 | 1.65*** | 1.67*** | 1.91*** | 1.57* | 1.57* |
| Haptoglobin | P00738 | 0.00014 | 1.65* | 2.08*** | 1.60* | 1.85*** | 2.19*** |
| Lipoprotein, Lp(A) | Q1HP67 | 0.00015 | 2.44* | 3.73** | 2.25* | 4.99** | 6.83*** |
| Serum amyloid A | D3DQX7 | 1.98E-05 | 0.49* | 35.57* | 3.47* | 3.65* | 22.86** |
| Serum amyloid A-1 | P0DJI8 | 0.00097 | 1.03 | 15.02* | 2.65* | 3.98* | 13.90* |
| Serum amyloid A-2 | P0DJI9 | 0.00299 | absent in HV | and CKD1-2 | 0.04* | 0.19* | 0.92 |
| Serum amyloid A-4 | P35542 | 0.0002 | 1.56* | 1.66** | 1.98** | 1.84* | 2.13*** |
| Serum amyloid P | P02743 | 0.02349 | 1.10* | 1.88** | 1.84* | 2.22* | 2.12* |
| Serum paraoxonase 1 | P27169 | 1.86E-07 | 1.12* | 0.33*** | 0.33*** | 0.50* | 0.52** |
| von Willebrand factor | L8E853 | 1.21E-05 | absent in HV | 1.35 | 1.51** | 0.40* | 0.40* |
Fold changes were calculated against the HV group; only in the case of the two proteins fold changes were calculated against the CKD1-2 (von Willebrand factor) or CKD3-4 (serum amyloid A-2) experimental group. *t-test P value < 0.05, **t-test P value < 0.005, ***t-test P value < 0.0005. Differences identified as significant (P < 0.05 and fold change >1.5 or <0.66) are in bold.