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. 2016 Sep 6;7(5):e00412-16. doi: 10.1128/mBio.00412-16

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Copyright © 2016 Morisaki et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — cro/cI mutations that are associated with resistance to SpsB inhibitor compound 103. (A) Predicted full-length amino acid sequence of Cro/CI protein. Amino acids that were found to be mutated in resistant clones are indicated in red, with their respective substitutions underneath. sc, stop codon; in, insertion of CGTTTCAAGCGGG resulting in multiple stop codons. (B) Single-base-pair substitutions that were found in the promoter region of the cro/cI open reading frame (ORF) and that were associated with resistance to compound 103 were located 62 bp and 14 bp upstream of the cro/cI ORF. All mutations inside (A) or upstream of (B) the cro/cI ORF are associated with a >16-fold increase in the MIC of compound 103.