Table 1. Baseline characteristics of patients in the trials included in the meta-analysis.
Study | Year | Intervention | No. of patients | Age(mean ± SD, y) | Duration of T2DM (mean ± SD, y) | Hb1Ac (mean ± SD, %) | Weight(mean ± SD, kg) | Jadad score |
---|---|---|---|---|---|---|---|---|
Nauck M19 | 2009 | 0.6 mg liraglutide | 242 | 56±11 | 7±5 | 8.4±0.9 | NR | 4 |
1.2 mgliraglutide | 242 | 57±9 | 7±5 | 8.3±1.0 | NR | |||
1.8 mg liraglutide | 242 | 57±9 | 8±5 | 8.4±1.0 | NR | |||
4 mg glimepiride | 123 | 57±9 | 8±5 | 8.4±1.0 | NR | |||
Placebo | 242 | 56±9 | 8±6 | 8.4±1.1 | NR | |||
Russell-Jones D20 | 2009 | 1.8 mg liraglutide | 232 | 57.6±9.5 | 9.2±5.8 | 8.3±0.9 | 85.5±19.4 | 4 |
Placebo | 115 | 57.5±9.6 | 9.4±6.2 | 8.3±0.9 | 85.7±16.7 | |||
24 IU insulin glargine | 234 | 57.5±10.5 | 9.7±6.4 | 8.2±0.9 | 85±17.9 | |||
Dungan KM41 | 2014 | 1.8 mg liraglutide | 300 | 56.8±9.9 | 7.3±5.4 | 8.1±0.8 | 94.4±19 | 4 |
1.5 mg dulaglutide | 299 | 56.5±9.3 | 7.1±5.4 | 8.1±0.8 | 93.8±18.2 | |||
Ma ZJ42 | 2015 | 1.8 mg liraglutide | 31 | 51.3±12.5 | NR | 10.1±1.4 | 77.3±2.1 | 3 |
NPH | 32 | 52.5±11.7 | NR | 9.8±1.8 | 76.7±2.3 | |||
Davies M43 | 2011 | 1.2 mg liraglutide | 164 | NR | NR | 8.4 | 93.7 | 3 |
1.8 mg liraglutide | 171 | NR | NR | 8.4 | 94.6 | |||
100 mg sitagliptin | 170 | NR | NR | 8.5 | 93.1 | |||
Brady EM44 | 2014 | 1.2 mg liraglutide | 47 | 51.5±11.1 | NR | 7.6±1.1 | 86.1±16.9 | 4 |
4 mg glimepiride | 52 | 52.2±10.7 | NR | 7.8±1.0 | 79±11.2 | |||
Yang W45 | 2011 | 0.6 mg liraglutide | 231 | 53.5±9.5 | 7.4±5.4 | 8.5±1.1 | 68.6±11.6 | 3 |
1.2 mg liraglutide | 233 | 53.5±9.6 | 7.5±5.3 | 8.6±1.1 | 67.4±11.3 | |||
1.8 mg liraglutide | 234 | 52.7±9.1 | 7.2±5.2 | 8.6±1.1 | 68.2±11.9 | |||
4 mg glimepiride | 231 | 53.6±9.7 | 7.8±6.1 | 8.5±1.1 | 68.2±11.9 | |||
Charbonnel B46 | 2013 | 1.2 mgliraglutide | 327 | 67.6±10.8 | 8.2±6.2 | 8.1±0.9 | 92.1±20.4 | 3 |
100 mg sitagliptin | 326 | 56.9±10 | 7.6±4.8 | 8.2±1.1 | 91±20.5 | |||
Pratley R40 | 2011 | 1.2 mgliraglutide | 135 | 55.9±9.6 | 6.0±4.5 | 8.4±0.8 | NR | 3 |
1.8 mg liraglutide | 150 | 55.0±9.1 | 6.4±5.4 | 8.4±0.7 | NR | |||
100 mg sitagliptin | 151 | 55.0±9.0 | 6.3±5.4 | 8.5±0.7 | NR |
Abbreviation: NR, not reported; SD, standard deviation.