Figure 7. SST4 receptor activation at the preBötC did not change rhythmic breathing but decreased genioglossus muscle amplitude in anesthetized rats.
Microperfusion of the SST4 receptor antagonist NNC 26–9100 (10 μM) into the preBötC of anaesthetized rats (a) decreased genioglossus muscle activity but not breathing rate and diaphragm amplitude (b). The microperfusion probe was located in the preBötC ventral to the nucleus ambiguus (c). NNC 26–9100 (10 μM) into the preBötC did not significantly change breathing rate (d) or diaphragm muscle amplitude (e), but significantly reduced genioglossus muscle amplitude (n = 4, f). *Indicate mean values significantly different from aCSF/baseline with P < 0.05. Data are indicated as means ± S.E.M and as individual values for each animal.