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. 2016 Sep 7;6:32648. doi: 10.1038/srep32648

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Images of CEST MRI kinetic measurements in mice bearing MCF7 tumors (human cancer cells) at different times following IV (a–d) and PO (e–h) administration of GlcN, 1.0 g/kg (B₁ = 2.4 μT, B₀ = 7 T). (a,e) A T₂-weighted image before administration of the agent (the conventional image). (b,f) A CEST image before administration of the agent (10.4% and 7.8% CEST in the whole tumor, respectively). (c,g) A CEST image 48 and 41 mins after administration of the agent (14.6% and 13.4% CEST in the whole tumor, respectively). (d,h) The time series of the % CEST achieved in the tumor.