TABLE III.
CAN1 Forward Mutation Rates in Strains Containing a pLYS- or pGAL-Regulated lys2-TAG Allele
| lys2-TAG Transcription level | CanR Ratea × 10−8 |
|||
|---|---|---|---|---|
| WT (95% CIb) | ogg1Δ (95% CI) | tsa1Δ (95% CI) | rev3Δ (95% CI) | |
| Low | 14.8 [1×] (11–18) |
52 [3.5×] (50–64) |
38 [2.6×] (26–73) |
6.0 [0.41×] (2.6–9.0) |
| High | 17.6 [1.2×] (14–31) |
63 [4.3×] (50–108) |
42 [2.8×] (32–72) |
7.0 [0.47×] (5.2–9.8) |
a
Bracketed values represent fold-increases relative to the low-transcription wild type rate.
b
CI, confidence interval.