Table 2.
Phenotypic frequencies of HLA-DRB1 alleles in patients with MS
| DRB1 | Phenotype frequency, n (%) | OR | 95 % CI | p uncorr | p corr | |
|---|---|---|---|---|---|---|
| MS (n = 434) | HCs (n = 394) | |||||
| 01:01 | 24 (5.5) | 53 (13.5) | 0.38 | 0.23–0.62 | <0.0001 | 0.003 |
| 03:03 | 1 (0.2) | 0 | NA | NA | 1.0000 | NS |
| 04:01 | 7 (1.6) | 9 (2.3) | 0.70 | 0.26–1.90 | 0.6151 | NS |
| 04:03 | 42 (9.7) | 22 (5.6) | 1.81 | 1.06–3.09 | 0.0276 | NS |
| 04:04 | 2 (0.5) | 2 (0.5) | 0.91 | 0.13–6.47 | 1.0000 | NS |
| 04:05 | 172 (39.6) | 100 (25.4) | 1.93 | 1.43–2.60 | <0.0001 | 0.0004 |
| 04:06 | 42 (9.7) | 26 (6.6) | 1.52 | 0.91–2.52 | 0.1071 | NS |
| 04:07 | 2 (0.5) | 4 (1.0) | 0.45 | 0.08–2.48 | 0.4317 | NS |
| 04:10 | 24 (5.5) | 8 (2.0) | 2.82 | 1.25–6.36 | 0.0091 | NS |
| 07:01 | 1 (0.2) | 2 (0.5) | 0.45 | 0.04–5.01 | 0.6073 | NS |
| 07:10 | 1 (0.2) | 0 | NA | NA | 1.0000 | NS |
| 08:01 | 1 (0.2) | 1 (0.3) | 0.91 | 0.06–14.56 | 1.0000 | NS |
| 08:02 | 38 (8.8) | 29 (7.4) | 1.21 | 0.73–2.00 | 0.4622 | NS |
| 08:03 | 63 (14.5) | 56 (14.2) | 1.02 | 0.69–1.51 | 0.9012 | NS |
| 09:01 | 72 (16.6) | 104 (26.4) | 0.55 | 0.40–0.78 | 0.0006 | 0.0198 |
| 10:01 | 2 (0.5) | 2 (0.5) | 0.91 | 0.13–6.47 | 1.0000 | NS |
| 11:01 | 18 (4.2) | 19 (4.8) | 0.85 | 0.44–1.65 | 0.6388 | NS |
| 12:01 | 26 (6.0) | 38 (9.6) | 0.60 | 0.36–1.00 | 0.0493 | NS |
| 12:02 | 5 (1.2) | 15 (3.8) | 0.29 | 0.11–0.82 | 0.0211 | NS |
| 13:01 | 3 (0.7) | 2 (0.5) | 1.36 | 0.23–8.21 | 1.0000 | NS |
| 13:02 | 20 (4.6) | 46 (11.7) | 0.37 | 0.21–0.63 | 0.0002 | 0.0066 |
| 13:07 | 0 | 1 (0.3) | 0 | NA | 0.4758 | NS |
| 14:01 | 3 (0.7) | 0 | NA | NA | 0.2508 | NS |
| 14:02 | 1 (0.2) | 1 (0.3) | 0.91 | 0.06–14.56 | 1.0000 | NS |
| 14:03 | 20 (4.6) | 14 (3.6) | 1.31 | 0.65–2.63 | 0.4449 | NS |
| 14:05 | 17 (3.9) | 15 (3.8) | 1.03 | 0.51–2.09 | 0.9347 | NS |
| 14:06 | 11 (2.5) | 6 (1.5) | 1.68 | 1.62–4.59 | 0.3371 | NS |
| 14:07 | 0 | 2 (0.5) | 0 | NA | 0.2261 | NS |
| 14:54 | 20 (4.6) | 28 (7.1) | 0.63 | 0.35–1.14 | 0.1245 | NS |
| 15:01 | 125 (28.8) | 67 (17.0) | 1.97 | 1.41–2.76 | <0.0001 | 0.0019 |
| 15:02 | 55 (12.7) | 83 (21.1) | 0.54 | 0.37–0.79 | 0.0012 | 0.0396 |
| 15:10 | 1 (0.2) | 0 | NA | NA | 1.0000 | NS |
| 16:02 | 4 (0.9) | 4 (1.0) | 0.91 | 0.23–3.65 | 1.0000 | NS |
p uncorr was corrected by multiplying the value by 33 to calculate p corr
CI confidence interval, HCs healthy controls, MS multiple sclerosis, NA not applicable, NS not significant, OR odds ratio, p corr corrected p value