Table 3.

Multivariable analysis for PFS adjusted by treatment and metastatic volume

	HR	95 % CI for HR	p-value
Mets Volume (High vs. Low)	2.66	(1.34, 5.27)	0.005
Treatment (ADT + Chemo vs. ADT)	1.09	(0.65, 1.84)	0.75
Insulin (ln)a (<2.1 vs. ≥2.1)	2.55	(1.24, 5.23)	0.011
HGF (ln)a (>8.9 vs. ≤8.9)	2.00	(1.08, 3.70)	0.027
OPN (ln)a (>11.9 vs. ≤11.9)	1.67	(0.84, 3.33)	0.147
C-peptide (ln) (Unit = 1000)	0.97	(0.86, 1.10)	0.622

OPN osteopontin, HGF hepatocyte growth factor

^aCut points were determined by CART analysis