Table 2.
Associations with breast cancer risk, by levels of MLL, histologic impression, and age
| MLL Absent | MLL Present | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | No. Women |
Observed Events |
Expected Events |
SIR (95% CI) |
No. Women |
Observed Events |
Expected Events |
SIR (95% CI) |
p-value |
| Overall | 13310 | 1250 | 765.66 | 1.63 (1.54, 1.73) | 102 | 13 | 5.70 | 2.28 (1.21, 3.91) | 0.255 |
| Age of BBD | |||||||||
| <45 | 4358 | 338 | 187.48 | 1.80 (1.62, 2.01) | 17 | 4 | 0.77 | 5.16 (1.41, 13.23) | 0.074 |
| 45–55 | 3888 | 448 | 264.55 | 1.69 (1.54, 1.86) | 42 | 6 | 2.22 | 2.70 (0.99, 5.87) | 0.292 |
| 55+ | 5064 | 464 | 313.63 | 1.48 (1.35, 1.62) | 43 | 3 | 2.70 | 1.11 (0.23, 3.24) | 0.604 |
| Overall impression | |||||||||
| NP | 8427 | 619 | 481.38 | 1.29 (1.19, 1.39) | 22 | 3 | 1.14 | 2.63 (0.54, 7.67) | 0.269 |
| PDWA | 4214 | 487 | 250.77 | 1.94 (1.77, 2.12) | 53 | 6 | 3.18 | 1.89 (0.69, 4.10) | 0.943 |
| AH | 669 | 144 | 33.51 | 4.30 (3.62, 5.06) | 27 | 4 | 1.37 | 2.91 (0.79, 7.46) | 0.413 |
Standardized incidence ratios and corresponding 95% confidence intervals, comparing the observed number of breast cancer events to those expected based on incidence rates from Iowa SEER data. Analyses account for the effects of age and calendar period.