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. 2016 Aug 31;7:12597. doi: 10.1038/ncomms12597

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Copyright © 2016, The Author(s)

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(a,b) Inhibition of Notch signalling in sorted Ly6C^hi monocytes using a γ-secretase inhibitor (DAPT) impairs conversion in vitro. Representative flow cytometry plot from live CD11b⁺GFP⁺ cells (a) and relative frequency (b) of Ly6C^lo monocyte-like cells (CD11b⁺GFP⁺Ly6C^lo/−CD11c^loCD43⁺MHC-II^lo/−) are shown. (c,d) Ly6C^hi monocytes from GFP⁺Notch2^ΔMy mice show impaired conversion. Representative flow cytometry plot (c) and relative frequency (d) of Ly6C^lo monocyte-like cells are shown (similar to Fig. 6a,b). (b,d) n=3, *P<0.05, **P<0.01, ***P<0.001; one-way ANOVA with Bonferroni's Multiple comparison test. Error bars represent s.e.m.