Figure 1.

Bioinformatic pipeline used to identify viral gene segments with sequence similarity to host proteins: characterized viruses versus characterized immune system (humans). Virus genomes were segmented into 200 base pair sequences to create a mock viral metagenome and compared with the human proteome using tBLASTn analysis with an e-value cutoff of less than 1 × 10⁻⁴. Viruses included human herpesviruses 1–3, 5, 6A, 6B, 7–8, human adenoviruses A-E, human circovirus, and human papillomaviruses 1, 2. See electronic supplementary material, table S1a, for description of viruses used in the analysis, electronic supplementary material, table S1b, for summary of human proteins identified, and electronic supplementary material, file S1 for full tBLASTn results.