FIG. 8.

Arc protein expression in cortices from offspring exposed in utero to B(a)P. Expression of Arc protein is shown to be virtually unchanged in home cage control and home cage B(a)P-exposed offspring (lanes 1–3). Conversely, Arc protein expression is shown to be significantly upregulated in B(a)P-exposed offspring that underwent spatial discrimination testing. The result suggests that the increase in protein expression was in response to acquisition of novelty in these offspring as compared with a lack thereof, in their home cage controls.