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. 2015 Oct 5;149(1):111–120. doi: 10.1093/toxsci/kfv213

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Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US.

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FIG. 5. — Mouse hepatic stellate cells (MHSC) expresses profibrogenic genes with CCl₄ administration that is attenuated by CDDO-EA. A, MHSC cells were isolated and purified. Flow as well as mRNA data show isolation purity of MHSC cells after depletion. B, MHSC cells isolated were stained with collagen-1a1 to assess degree of activation. Pictogram shows a representative figure. C, mRNA expression in MHSCs of tissue remodeling cytokines. D, mRNA expression in MHSCs of inflammatory cytokines. E, mRNA expression of fibrogenetic cytokines were measured at week 30 after CCl₄ versus CCl₄ for 12 week followed by 18 weeks of CDDO-EA+ CCl₄. (F) mRNA expression in MHSCs for Nrf-2 and HO-1 as well as protein levels of HO-1 and Nqo-1 were measured. Data are presented as mean ± SE of all mice (N = 10 per group). Each figure legend depicts an independently performed 2 experiments. *P < .05, **P < .01, *** P < .001.