FIG. 4.

There are no changes in DAT expression or binding in synaptosomes prepared from wild-type and VMAT2-HI mice. A, Representative immunoblotting of VMAT2 and dopaminergic markers DAT and TH between wild-type and VMAT2-HI mice from synaptosomal preparations from wild-type and VMAT2-HI mice (n = 4). B, VMAT2 level is significantly increased in the VMAT2-HI mice. C and D, There are no differences in the expression levels of DAT and TH between wild-type and VMAT2-HI mice. E, Using isolated synaptosomal preparations from bilateral dissected striatal homogenates, WIN binding showed no significant differences in DAT level between genotypes (n = 4).