Table 2.
Top 10 ranked differentially methylated positions in ulcerative colitis (n = 61) compared with controls (n = 39).
| Probe ID | Mean ∆β | p value | Adjusted p | Hg19 | Illumina annotation | Probe type | Gene annotation from GREAT (distance from TSS) |
|---|---|---|---|---|---|---|---|
| cg16176675 | 0.084 | 5.07e–17 | 2.19e–11 | Chr5: 134786942 | TIFAB | II | C5orf20 (–3905) |
| cg02619001 | 0.075 | 3.46e–16 | 1.49e–10 | Chr17: 47592333 | NGFR | II | NXPH3 (–60964), NGFR (+19679) |
| cg07795766 | 0.051 | 1.84e–15 | 7.95e–10 | Chr22: 45608516 | C22orf9 | I | UPK3A (–72351), NUP50 (+48791) |
| cg21935981 | 0.068 | 2.38e–15 | 1.02e–09 | Chr22: 45608465 | C22orf9 | I | UPK3A (–72402), NUP50 (+48740) |
| cg20061654 | 0.074 | 2.67e–15 | 1.15e–09 | Chr22: 45608492 | C22orf9 | I | UPK3A (–72375), NUP50 (+48767) |
| cg23320499 | –0.077 | 5.76e–15 | 2.48e–09 | Chr12: 12659177 | DUSP16 | II | MANSC1 (–156009), DUSP16 (+56270) |
| cg04223044 | 0.072 | 6.67e–15 | 2.87e–09 | Chr22: 45608428 | C22orf9 | II | UPK3A (–72439), NUP50 (+48703) |
| cg19380303 | 0.082 | 7.60e–15 | 3.27e–09 | Chr15: 90172193 | KIF7 | I | KIF7 (+26488), C15orf42 (+53376) |
| cg04407417 | 0.041 | 7.81e–15 | 3.36e–09 | Chr12: 52228651 | II | FIGNL2 (–2951) | |
| cg10311161 | 0.086 | 1.05e–14 | 4.51e–09 | Chr8: 68110902 | ARFGEF1 | II | CSPP1 (+134300), ARFGEF1 (+145009) |
Adjusted p, Bonferroni-corrected p value; Hg19, Human Genome version 19; GREAT, Genomic Regions Enrichment of Annotations Tool; TSS, transcription start site.