Table 4.
Top 10 ranked differentially methylated positions (DMPs) in 149 patients comparing active (n = 79) with inactive (n = 70) inflammatory bowel disease.
| Probe ID | Mean ∆β | p value | Adjusted p | Hg19 | Illumina annotation | Probe type | Gene annotation from GREAT (distance from TSS) |
|---|---|---|---|---|---|---|---|
| cg11971248 | 0.011 | 1.79e–06 | 0.771 | Chr4: 84203337 | COQ2 | II | COQ2 (+2729), COPS4 (+247099) |
| cg26455541 | 0.007 | 2.48e–06 | 1 | Chr4: 26321238 | RBPJ | I | RBPJ (–1190) |
| cg10724442 | 0.004 | 2.87e–06 | 1 | Chr19: 40971809 | SPTBN4; BLVRB | I | SPTBN4 (–1316), BLVRB (–85) |
| cg21494337 | 0.006 | 2.88e–06 | 1 | Chr2: 25015597 | CENPO; C2orf79 | II | CENPO (–733), PTRHD1 (+653) |
| cg15613012 | –0.010 | 3.40e–06 | 1 | Chr6: 28887742 | TRIM27 | II | SCAND3 (–332631), TRIM27 (+4025) |
| cg21218864 | 0.017 | 3.41e–06 | 1 | Chr1: 206730120 | RASSF5 | II | RASSF5 (+49242), EIF2D (+55783) |
| cg17440044 | 0.017 | 4.05e–06 | 1 | Chr7: 100167198 | II | SAP25 (+4071), AGFG2 (+30365) | |
| cg22380652 | 0.006 | 4.57e–06 | 1 | Chr1: 43389667 | II | SLC2A1 (+35179), ZNF691 (+77424) | |
| cg27386912 | 0.007 | 4.64e–06 | 1 | Chr3: 52479108 | SEMA3G | II | SEMA3G (–66) |
| cg02712401 | 0.004 | 5.60e–06 | 1 | Chr12: 6961946 | USP5; CDCA3 | II | CDCA3 (–1491), USP5 (+662) |
Adjusted p; Bonferroni corrected p value; Hg19, Human Genome version 19; GREAT, Genomic Regions Enrichment of Annotations Tool; TSS, transcription start site.