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. 2016 Jun;101(6):741–746. doi: 10.3324/haematol.2015.135137

Table 2.

Post-transplant evolution of chimerism in whole blood and selected cell lineages. Within the entire cohort of 162 pediatric patients with ALL undergoing rescue therapy by allogeneic HSCT, chimerism was successfully analyzed within total leukocytes from peripheral blood (total PB), and specific cell fractions isolated by flow sorting from PB in the indicated number of instances. Enrichment of CD34+ cells from PB by flow sorting was achievable in 91/162 patients, but the cell numbers were sufficient for subsequent analysis of chimerism in 62 cases only. The leukocyte lineages statistically correlating in univariate analysis with the risk of relapse, including the CD8+ and the CD34+ cell subsets, are displayed, and the respective numbers of patients who reached complete donor chimerism (DC) or switched to MC after previous documentation of DC (DC→MC) are indicated. The 5-year cumulative risk of relapse (CIR) and the hazard ratios (HR) derived from a Cox-regression analysis with time-dependent covariates are indicated with the corresponding 95% confidence intervals (CI). The CD19+/CD34 cell lineage in which the presence of MC correlated with decreased CIR (statistically not significant) is shown for comparison.

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