Table 3.

Multivariate analysis of risk factors for relapse after allogeneic HCST. In addition to the reappearance of mixed chimerism (MC) in the leukocyte subsets CD34⁺, CD8⁺ and total peripheral blood (indicated as →MC in the Table), the influence of additional factors including the remission status before HSCT and the type of donor, which indicated a correlation with relapse risk in univariate analysis, were subjected to multivariate analysis. While the donor type had no influence on the relapse risk in this setting, the achievement of first or second complete remission prior to HSCT was significantly correlated with a decreased risk of relapse. Immunophenotype was not associated with higher relapse hazards and the results remained essentially unchanged when immunophenotype was added to the model. Reappearing MC in the indicated cell populations remained an independent risk factor for ensuing leukemia relapse even after adjustment for all other variables tested. The 95% confidence intervals (95%CI) of the calculated hazard ratios are indicated.