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Map of the human HBV genome highlighting the multiple overlapping HBV ORFs and transcripts (RefSeq: NC_003977.1; GenBank:X04615.1). The inner ring represents the main HBV ORFs whereas the outer ring represents the main HBV transcripts. Most of the elements of the PRE (light gray shading) are present in all the main HBV transcripts. At least 2 of the 3 conserved RNA stem-loops (dark gray shadings), SLα, SLβ, and ɛ are present in all the main HBV transcripts.
