Table 1.
FDR-corrected probes that associate with ADHD trajectory. Estimates given for birth and age 7, ranked by birth p-values. Chr, chromosome; StdB, standardized regression beta (negative values indicate hypomethylation in the high trajectory group); p, uncorrected p-value; q, FDR-corrected value; s.d., standard deviation.
| CpG | Gene | Chr | Position | Birth | Age 7 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| StdB | p | q | mean±s.d. low trajectory group | mean±s.d. high trajectory group | StdB | p | q | mean±s.d. low trajectory group | mean±s.d. high trajectory group | ||||
| cg24481594 | SKI | 1 | 2190850 | -0.198 | 1.51E-08 | 0.006 | 0.828 (0.026) | 0.805 (0.034) | 0.005 | 0.876 | 0.963 | 0.777 (0.025) | 0.777 (0.024) |
| cg03905179 | MAFK | 7 | 1582588 | -0.182 | 2.00E-07 | 0.031 | 0.761 (0.040) | 0.727 (0.076) | -0.002 | 0.951 | 0.963 | 0.753 (0.034) | 0.752 (0.028) |
| cg27469152 | EPX | 17 | 56282313 | -0.181 | 2.26E-07 | 0.031 | 0.793 (0.024) | 0.771 (0.032) | -0.090 | 0.008 | 0.104 | 0.772 (0.032) | 0.758 (0.030) |
| cg15096815 | JUN | 1 | 59249838 | -0.178 | 3.53E-07 | 0.036 | 0.105 (0.010) | 0.097 (0.009) | 0.002 | 0.963 | 0.963 | 0.104 (0.010) | 0.104 (0.010) |
| cg01324543 | CCDC30 | 1 | 42999439 | -0.174 | 7.21E-07 | 0.048 | 0.871 (0.025) | 0.851 (0.036) | 0.023 | 0.497 | 0.881 | 0.876 (0.020) | 0.877 (0.022) |
| cg16290904 | PEX2 | 8 | 77912348 | 0.173 | 7.35E-07 | 0.048 | 0.055 (0.006) | 0.061 (0.017) | -0.077 | 0.022 | 0.143 | 0.061 (0.011) | 0.058 (0.013) |
| cg26263766 | ZNF544 | 19 | 58739734 | 0.173 | 8.72E-07 | 0.048 | 0.064 (0.019) | 0.079 (0.032) | 0.012 | 0.729 | 0.948 | 0.063 (0.020) | 0.064 (0.025) |
| cg09989037 | ST3GAL3 | 1 | 44300942 | -0.172 | 9.46E-07 | 0.048 | 0.443 (0.055) | 0.402 (0.069) | -0.056 | 0.099 | 0.322 | 0.463 (0.044) | 0.454 (0.048) |
| cg18587973 | CDADC1 | 13 | 49822535 | 0.170 | 1.20E-06 | 0.048 | 0.076 (0.034) | 0.108 (0.092) | -0.015 | 0.656 | 0.948 | 0.086 (0.029) | 0.085 (0.039) |
| cg22193912 | MAFG | 17 | 79881523 | 0.169 | 1.28E-06 | 0.048 | 0.171 (0.056) | 0.218 (0.082) | -0.041 | 0.224 | 0.570 | 0.311 (0.053) | 0.303 (0.063) |
| cg13714586 | FBXW5 | 9 | 139838358 | 0.170 | 1.30E-06 | 0.048 | 0.049 (0.005) | 0.055 (0.026) | -0.038 | 0.263 | 0.570 | 0.050 (0.007) | 0.049 (0.005) |
| cg05653018 | ELF3 | 1 | 201979533 | 0.169 | 1.43E-06 | 0.048 | 0.799 (0.045) | 0.833 (0.035) | 0.059 | 0.082 | 0.322 | 0.841 (0.027) | 0.847 (0.021) |
| cg24843380 | ZNF454 | 5 | 178367827 | 0.168 | 1.56E-06 | 0.049 | 0.075 (0.010) | 0.087 (0.053) | 0.021 | 0.542 | 0.881 | 0.093 (0.021) | 0.096 (0.015) |