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. Author manuscript; available in PMC: 2016 Sep 7.
Published in final edited form as: Brain Behav Immun. 2016 Feb 23;56:140–155. doi: 10.1016/j.bbi.2016.02.020

Fig. 4. Distinct microbial metabolite levels in the colonic contents are markedly decreased by antibiotic treatment.

Fig. 4

Mice were treated with antibiotic (AB) mix or vehicle (VEH) by gavage for 11 days. (A) Scores plot of the principal component analysis (PCA) with 21 identified colonic metabolites analyzed by 1H NMR, showing group separation in the first and fourth components. (B) Corresponding loadings plot, showing the contribution of metabolites to group separation. The metabolites are colored according to p-values calculated with the Mann-Whitney U test. (C) Graphs of significantly different metabolites. Vertical bars represent the group mean, whiskers SD, n=10-12; **p ≤ 0.01, ***p ≤ 0.001 compared to VEH-treated mice, Mann-Whitney U test.