Fig. 6. Object recognition memory is impaired in antibiotic-treated mice whereas spatial learning and memory remain intact.
Mice were treated with antibiotic (AB) mix or vehicle (VEH) by gavage for 11 days. In the NORT (A) a positive memory index (MI) indicates that the mice spent more time exploring the novel object than the known object. In the BM test (B,C) panel B shows the decrease in target latency with consecutive training trials, and panel C shows memorization of the target hole in the target quadrant on the probe day. Values represent means + SEM, n=6-8 (A), n=7-8 (B), n=6-7 (C); *p ≤ 0.05 compared to VEH-treated mice, t-test.