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Results of the secondary study aim, which was to assess how OEF and CBF varied for SCA participants with less or more impairment as defined by clinical criteria. OEF (A) was elevated in more impaired patients (P < 0.001), whereas CBF (B) was not different (P = 0.088) between SCA groups with different levels of impairment, likely due to multiple competing effects related to reduced oxygen carrying capacity and steno-occlusion.
