Table 1.
Summary of study participants with and without SCA
| Variables | Control participants (n = 11) | SCA participants (n = 27) |
|---|---|---|
| Age (years) | 26.9 ± 5.1 | 27.7 ± 5.0 |
| Sex (% male) | 45 | 59 |
| Race (% African-American) | 100 | 100 |
| Systolic blood pressure (mmHg) | 111 ± 12 | 118 ± 15 |
| Diastolic blood pressure (mmHg) | 67 ± 13 | 69 ± 12 |
| Haematocrit (%) | 42.1 ± 5.3 | 27.2 ± 3.6 |
| Haemoglobin S (%) | 0 | 64.8 ± 20.6 |
| Arterial oxygen saturation(%; measured by pulse oximetry) | 97.3 ± 1.2 | 95.2 ± 1.8 |
| Venous oxygen saturation(%; measured from TRUST) | 63.2 ± 6.1 | 52.0 ± 7.5 |
| OEF (%) | 35.0 ± 6.1 | 45.3 ± 7.5 |
| CBF (ml blood/100 g tissue/ minute) | 44.1 ± 5.2 | 51.0 ± 6.5 |
| Venous blood water T2 (ms) | 66.2 ± 11.3 | 77.5 ± 10.4 |
| Grey matter volume / intracranial volume | 0.388 ± 0.017 | 0.388 ± 0.026 |
| White matter volume / intracranial volume | 0.413 ± 0.018 | 0.395 ± 0.022 |
| CSF volume / intracranial volume | 0.199 ± 0.013 | 0.216 ± 0.018 |
SCA participants are those used for testing the primary hypothesis of the study and are not on blood transfusion. All values are mean ± SD. Grey matter volume and white matter volume units are mm3 but when normalized for intracranial volume, the ratio is dimensionless.