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. 2015 Sep 9;524(4):783–806. doi: 10.1002/cne.23865

Figure 8.

Figure 8

Grid‐like arrangement of calbindin‐positive pyramidal cells in the human entorhinal cortex. A: Overview of the human temporal lobe showing the entorhinal cortex close to the substantia nigra. B: Tangential section through entorhinal cortex oriented as in A and stained for calbindin and neurofilament immunoreactivity (SMI‐32). This figure was assembled from two different sections stained in the same way to show a larger number of calbindin‐positive patches. Stippled boxes indicate the location of panels C–F and G–J. Stippled line surrounds the caudal calbindin patch region and thus marks the caudal border of the entorhinal cortex. C: High‐magnification view of calbindin immunoreactivity in a tangential section of human caudal entorhinal cortex. D: Two‐dimensional spatial autocorrelation of the respective panel to the left revealing a hexagonal spatial organization of calbindin‐positive patches. Grid score is 0.71. E: High‐magnification view of SMI‐32 immunoreactivity in a tangential section of human caudal entorhinal cortex. F: Two‐dimensional spatial autocorrelation of the respective panel to the left revealing a lack of spatial organization. Grid score is –0.03. G: High‐magnification view of calbindin immunoreactivity in a tangential section of human rostral entorhinal cortex. H: Two‐dimensional spatial autocorrelation of the respective panel G revealing a less regular spatial organization than in D. Grid score is –0.18. I: High‐magnification view of SMI‐32 immunoreactivity in a tangential section of human rostral entorhinal cortex. J: Two‐dimensional spatial autocorrelation of the respective panel to the left revealing a little regularity in spatial organization. Grid score is 0.19. A magenta–green version of this figure has been provided as an online supporting file for the assistance of color‐blind readers. C, caudal; L, lateral; M, medial; R, rostral. Scale bar = 1 cm in B; 1 mm in E (also applies to C); 1 mm in F (also applies to D); 1 mm in I (also applies to G); 1 mm in J (also applies to H).