Table 1.
Trial randomization methods and baseline similarity of groups.
| Trial | Sequence generation methoda | Risk of bias from allocation concealment methodsa | Important imbalance identified?b | Number randomized (number of groups) |
|---|---|---|---|---|
| Review: Resuscitation of newborns with room air or pure oxygen (Saugstad et al., 2008) | ||||
| Bajaj et al., 2005 | Quasi‐random | High | No | 204 (2) |
| Ramji et al., 1993 | Quasi‐random | High | No | 84 (2) |
| Ramji et al., 2003 | Quasi‐random | High | No | 433 (2) |
| Saugstad et al., 1998 | Quasi‐random | High | No | 703 (2) |
| Toma, 2006a | Truly random | Unclear | No | 54 (2) |
| Toma, 2006b | Truly random | Unclear | No | 44 (2) |
| Toma, 2007 | Truly random | Unclear | No | 56 (2) |
| Vento, 2001 | Truly random | Unclear | No | 527 (2) |
| Vento, 2003 | Truly random | Unclear | No | 151 (2) |
| Vento, 2005 | Truly random | Unclear | No | 53 (2) |
| Review: Endotracheal intubation in meconium‐stained newborns (Halliday and Sweet, 2001) | ||||
| Linder et al., 1988 | Quasi‐random | High | No | 572 (2) |
| Wiswell et al., 2000 | Truly random | High | Unclear | 2094 (2) |
| Review: Colloids versus crystalloids for fluid resuscitation in critically ill patients (Perel and Roberts, 2011) | ||||
| Evans et al., 1996 | Quasi‐random | High | No | 25 (2) |
| Bulger et al., 2011 | Truly random | Low | No | 895 (3) |
| James et al., 2011 | Truly random | Low | Yes | 115 (4) |
| Review: Timing and volume of fluid administration for patients with bleeding (Kwan et al., 2003) | ||||
| Bickell et al., 1994 | Quasi‐random | High | No | 598 (2) |
| Dutton, 2002 | Truly random | Low | No | 110 (2) |
| Turner et al., 2000 | Truly random | High | No | 1309c (2) |
| Review: Hypertonic versus near isotonic crystalloids for fluid resuscitation in critically ill patients (Bunn et al., 2004) | ||||
| Caldwell and Bowser, 1979 | Quasi‐random | High | Unclear | 37 (2) |
| Cooper et al., 2004 | Truly random | Low | No | 229 (2) |
| Vassar et al., 1993 | Truly random | Low | Yes | 233 (4)d |
| Review: Hypothermia for neuroprotection after cardiopulmonary resuscitation (Arrich et al., 2009) | ||||
| Bernard et al., 2002 | Quasi‐random | High | Yes | 84 (2) |
| HACA, 2002 | Truly random | Low | No | 275 (2) |
| Laurent, 2005 | Truly random | Low | Yes | 61 (3) |
| Review: Intubation for acutely ill and injured patients (Lecky et al., 2008) | ||||
| Gausche et al., 2000 | Quasi‐random | High | No | 830 (2) |
| Rabitsch et al., 2003 | Quasi‐random | High | Yes | 172 (2) |
| Goldenberg, 1986 | Truly random | High | Yes | 175 (2) |
a
See Supporting information S1 for details.
b
See Supporting information S1 and S2 for details.
c
Paramedics were randomized, with 1309 patients subsequently recruited.
d
Baseline data only presented for 194 patients (as 39 were ineligible).