Table 2.

Trial accrual and recruitment data.

Trial	Sequence generation method	Target sample size	Patients randomized	RA ratea	No. of eligible patients not randomized	No. of ineligible patients randomized
Review: Resuscitation of newborns with room air or pure oxygen (Saugstad et al., 2008)
Bajaj et al., 2005	Quasi‐random	146	204	14	0	0
Ramji et al., 1993	Quasi‐random	72	84	–c	0	0
Ramji et al., 2003	Quasi‐random	300	433	4	0	2
Saugstad et al., 1998	Quasi‐random	648	703	3	107	90
Toma, 2006a	Truly random	NR	54	–c	NR	NR
Toma, 2006b	Truly random	NR	44	15	NR	NR
Toma, 2007	Truly random	NR	56	–c	NR	NR
Vento, 2001	Truly random	NR	527	–c	NR	NR
Vento, 2003	Truly random	NR	151	–c	NR	24
Vento, 2005	Truly random	NR	53	1	Unclear, although 3 ‘improperly randomized’	0
Review: Endotracheal intubation in meconium‐stained newborns (Halliday and Sweet, 2001)
Linder et al., 1988	Quasi‐random	NR	572	18	0	0
Wiswell et al., 2000	Truly random	2058	2094	6	NR	Unclear
Review: Colloids versus crystalloids for fluid resuscitation in critically ill patients (Perel and Roberts, 2011)
Evans et al., 1996	Quasi‐random	NR	25	25	NR	0
Bulger et al., 2011	Truly random	3726	895	0.3	NR	23
James et al., 2011	Truly random	140	115	3	0	5
Review: Timing and volume of fluid administration for patients with bleeding (Kwan et al., 2003)
Bickell et al., 1994	Quasi‐random	~600	598	16	0	471
Dutton, 2002	Truly random	NR	110	6	NR	NR
Turner et al., 2000	Truly random	NRb	1309	5	0	0
Review: Hypertonic versus near isotonic crystalloids for fluid resuscitation in critically ill patients (Bunn et al., 2004)
Caldwell and Bowser, 1979	Quasi‐random	NR	37	1	NR	NR
Cooper et al., 2004	Truly random	220	229	0.5	0	0
Vassar et al., 1993	Truly random	600	233	2	0	39
Review: Hypothermia for neuroprotection after cardiopulmonary resuscitation (Arrich et al., 2009)
Bernard et al., 2002	Quasi‐random	62	84	0.6	0	0
HACA, 2002	Truly random	NR	275	0.6	30	0
Laurent, 2005	Truly random	90	61	1	0	0
Review: Intubation for acutely ill and injured patients (Lecky et al., 2008)
Gausche et al., 2000	Quasi‐random	800	830	–c	1	None
Rabitsch et al., 2003	Quasi‐random	NR	172	14	NR	NR
Goldenberg, 1986	Truly random	NR	175	7	0	~10

RA, randomization; NR, not reported.

^aEstimated monthly rate, per centre.

^bNot reported for patients but 420 for paramedics.

^cUnable to calculate an estimate.