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. Author manuscript; available in PMC: 2016 Sep 7.

Published in final edited form as: Toxicol Appl Pharmacol. 2011 Feb 17;252(1):1–10. doi: 10.1016/j.taap.2011.02.001

Chromosomal changes induced by fibrous nanomaterials: (A) Micronucleated cell induction in 1000 scored cells after challenge with CNF, SWCNT or asbestos in V79 cells. ■ – exposure with CNF; ↑ – exposure with asbestos, – exposure with SWCNT. Data are shown as mean values ± SEM (n=3 experiments); *p<0.05, vs control; ^αp<0.05, vs 3 μg/cm² of the same treatment. (B) Number of centromere-positive and centromere-negative MN in SEAC incubated with CNF (2.4 and 24 μg/cm²). Data are shown as mean values ± SEM; *p<0.05, vs control. (C) Centromere-positive (aneugenic) and (D) centromere-negative (clastogenic) MN after exposure to 2.4 mg/cm² CNF. Arrows indicate CNF within a nucleus.

Inline graphic — Chromosomal changes induced by fibrous nanomaterials: (A) Micronucleated cell induction in 1000 scored cells after challenge with CNF, SWCNT or asbestos in V79 cells. ■ – exposure with CNF; ↑ – exposure with asbestos, – exposure with SWCNT. Data are shown as mean values ± SEM (n=3 experiments); *p<0.05, vs control; ^αp<0.05, vs 3 μg/cm² of the same treatment. (B) Number of centromere-positive and centromere-negative MN in SEAC incubated with CNF (2.4 and 24 μg/cm²). Data are shown as mean values ± SEM; *p<0.05, vs control. (C) Centromere-positive (aneugenic) and (D) centromere-negative (clastogenic) MN after exposure to 2.4 mg/cm² CNF. Arrows indicate CNF within a nucleus.