Table 3. Cut-offs for low-moderate and moderate-high disease activity in HUPI.

Population	Disease activity	AUC	Cut-off point	Se	Sp	LR +	LR -
PEARL	Low—Moderate	0.909	>5	72%	89%	3.18	0.15
EMECAR	Low—Moderate	0.945	>5	81%	92%	10.03	0.21
PEARL	Moderate–High	0.887	≥9	72%	90%	3.24	0.14
EMECAR	Moderate–High	0.937	≥9	70%	93%	10.45	0.32

HUPI: Hospital Universitario Princesa Index; AUC: area under curve; Se, sensitivity; Sp, specificity; LR: likelihood ratio EMECAR: Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide; PEARL: Princesa Early Arthritis Register Longitudinal.