Table 6. Computed tomography perfusion parameters (percentage change from baseline to Week 2) correlated to dysphagia severity at 3- and 6-month follow-up: Multivariate analysis.

Parameter	Dysphagia Grade 0–2			Dysphagia Grade 3			Δ Mean	p
	n	Mean	SE	n	Mean	SE
Blood flow
3-mo follow-up
Crude	10	43.0	38.8	5	130.5	54.8	−87.5	0.083
Adjusted for pack-years	10	40.2	40.4	5	136.1	57.7	−95.8	0.098
Adjusted for GTV-tumor – max	10	43.3	40.4	5	129.9	57.2	−86.5	0.096
Adjusted for baseline dysphagia	10	31.4	38.1	5	153.7	55.1	−122.2	0.043
6-mo follow-up
Crude	9	12.3	34.6	6	161.9	42.4	−149.6	0.007
Adjusted for pack-years	9	9.7	35.6	6	165.9	43.7	−156.1	0.010
Adjusted for GTV-tumor – max	9	12.4	35.9	6	161.8	44.0	−149.4	0.010
Adjusted for baseline dysphagia	9	4.0	32.4	6	174.4	39.9	−170.4	0.004
Blood volume
3-mo follow-up
Crude	10	12.0	27.2	5	107.7	38.5	−95.7	0.044
Adjusted for pack-years	10	12.1	28.6	5	107.4	40.9	−95.3	0.065
Adjusted for GTV-tumor – max	10	11.0	28.0	5	109.7	39.7	−98.7	0.039
Adjusted for baseline dysphagia	10	19.7	27.0	5	92.2	39.0	−72.4	0.120
6-mo follow-up
Crude	9	8.7	29.1	6	96.6	35.6	−87.8	0.039
Adjusted for pack-years	9	9.4	30.4	6	95.7	37.4	−86.3	0.055
Adjusted for GTV-tumor – max	9	8.6	30.0	6	96.8	36.9	−88.1	0.042
Adjusted for baseline dysphagia	9	15.2	27.7	6	86.9	34.1	−71.6	0.067
Capillary permeability
3-mo follow-up
Crude	9	31.6	33.8	4	−48.3	50.6	79.9	0.090
Adjusted for pack-years	9	33.0	35.6	4	−51.4	54.0	84.4	0.072
Adjusted for GTV-tumor – max	9	27.0	32.0	4	−38.0	48.3	64.9	0.126
Adjusted for baseline dysphagia	9	31.6	35.6	4	−48.2	53.8	79.8	0.132
6-mo follow-up
Crude	8	43.1	34.3	5	−50.7	43.4	93.8	0.062
Adjusted for pack-years	8	44.0	36.0	5	−52.1	45.7	96.0	0.058
Adjusted for GTV-tumor – max	8	40.8	31.5	5	−47.0	39.8	87.8	0.066
Adjusted for baseline dysphagia	8	42.9	35.9	5	−50.4	45.5	93.3	0.068

GTV-tumor – max is defined in Table 1 footnote. Δ Mean is the difference between mean percentage change from baseline to Week 2 of radiotherapy for Grade 0–2 and Grade 3 dysphagia patients.