Table 1.

Mechanisms by which different models account for experimentally observed cargo behavior.

Model	Experimentally Observed Cargo Behavior
	End of run	Pause state	Rescue from pause
Tug-of-War	Stall due to stochastic motor detachment or attachment of opposing motor	Both motors stalled in “a draw” (with potential cargo deformation).	One motor wins, other motor detaches or backsteps (with potential recoil of cargo)
Microtubule Tethering	Motor switches to diffusive state	Both motors bound in diffusive state	Motor switches to moving state
Mechanical Activation	Motor switches into inactive state	Either both detached or both bound and stalled	Thermal or motor-driven mechanical activation
Steric Disinhibition	Motor switches into inhibited state	Both detached, or one or both attached but inactive	Release from inhibited state