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. Author manuscript; available in PMC: 2016 Sep 7.
Published in final edited form as: Hum Mutat. 2015 Apr 27;36(6):599–610. doi: 10.1002/humu.22775

Figure 4.

Figure 4

Differential transcriptional activity of NR2E3 LBD variant proteins. HEK293T cells were transiently transfected with rhodopsin (A) or M-opsin (B) luciferase reporter constructs. NRL (N) and CRX (C) were cotransfected when indicated. Luciferase activity was normalized to β-galactosidase activity. Four to six independent experiments were performed in duplicates and SEM indicated. For statistical analysis, one-way ANOVA followed by Dunnett’s multiple comparison test, comparing the mean of each column with the mean of the NRL/CRX/NR2E3 wild-type (N/C/NR2E3wt) column was performed. *: p<0.05; **<0.01; ***: p<0.001; ****: p<0.0001.