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. Author manuscript; available in PMC: 2016 Sep 7.
Published in final edited form as: Otolaryngol Head Neck Surg. 2016 Mar 1;154(6):1149–1154. doi: 10.1177/0194599816632177

Figure 4.

Figure 4

Figure 4

Figure 4

Figure 4

(A) Olfactory marker protein (OMP) immunohistochemistry of wild type control mice. Green staining indicates OMP, and blue staining is the nuclear marker, DAPI (250×). The white broken line indicates the basement membrane.; (B) OMP staining of IOI mice after administration of doxycycline for 6 weeks. The olfactory epithelium was significantly thinned, and considerable loss of olfactory receptor neurons was observed; (C) Neural cell adhesion molecule (NCAM) immunohistochemistry of wild type control mice. Red staining is NCAM (250×). Scale bar = 25µm; (D) NCAM staining of 6-week IOI mice. The diameter of the subepithelial axon bundle was significantly reduced.