Table 5.

Multivariate Cox proportional hazards models for recurrence-free survival in association with homogeneous/heterogeneous PTEN loss by ERG status

Model and factor	Comparison	HR (95% CI)	p value
All patients
(n = 808, 371 events)
log(PSA)	1-unit increase	1.44 (1.22–1.70)	<0.0001
PTEN status	Homogeneous loss vs intact	1.66 (1.22–2.24)	0.001
	Heterogeneous loss vs intact	1.24 (0.93–1.65)	0.14
Margins	Positive vs negative	1.73 (1.39–2.16)	<0.0001
Seminal vesicle invasion	Yes vs no	1.93 (1.38–2.71)	0.0001
Extraprostatic extension	Yes vs no	1.30 (1.03–1.63)	0.03
Gleason score	3 + 4 vs 6	1.15 (0.89–1.48)	0.29
	4 + 3 vs 6	1.87 (1.38–2.54)	<0.0001
	8–10 vs 6	1.50 (1.06–2.11)	0.02
ERG-positive
(n = 284, 120 events)
log(PSA)	1-unit increase	1.56 (1.17–2.07)	0.002
PTEN status	Homogeneous loss vs intact	3.07 (1.94–4.84)	<0.0001
	Heterogeneous loss vs intact	1.46 (0.93–2.30)	0.10
Margins	Positive vs negative	1.88 (1.30–2.72)	0.0008
Seminal vesicle invasion	Yes vs no	3.55 (1.85–6.79)	0.0001
ERG-negative
(n = 454, 220 events)
log(PSA)	1-unit increase	1.51 (1.22–1.86)	0.0001
Gleason score	3 + 4 vs 6	1.24 (0.89–1.73)	0.20
	4 + 3 vs 6	2.01 (1.37–2.96)	0.0004
	8–10 vs 6	1.78 (1.16–2.72)	0.008
Margins	Positive vs negative	1.82 (1.38–2.41)	<0.0001
Extraprostatic extension	Positive vs negative	1.45 (1.09–1.92)	0.01

HR = hazard ratio; CI = confidence interval; PSA = prostate-specific antigen.