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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Stat Biosci. 2014 Jul 17;8(1):159–180. doi: 10.1007/s12561-014-9117-1
  1. Initial run-in. Start the trial and randomize n < N patients equally to T treatments in the set Ω.

  2. Treatment exclusion and early stopping. Drop treatment t* if q(t*, h) < q(t, h) for all tt* and h = 1, …, H. Set Ω = Ω \ {t*}. If enrollment remains active only for a single treatment t then stop the trial.

  3. Adaptive patient allocation. Allocate patient (n + 1) to treatment zn+1 according to (9). When the response yn+1 is available, go back to step 2 and repeat for patients n + 2, n + 3, …, N.

    Reporting patient subpopulations. Upon conclusion of the trial we report the estimated partition 3 together with the estimated optimal treatment allocations.