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. 2016 Sep 7;11(9):e0162351. doi: 10.1371/journal.pone.0162351

Fig 8. Humoral Ab responses against anti-RVA VHH in mice treated with anti-VP6 VHH.

Fig 8

The panel above shows seric IgG Ab response against anti-VP6 VHH in neonatal mice that received oral therapeutic treatment for seven days, consisting of: 2KD1 (200 μg), 3B2 (200 μg) and 2KD1+3B2 (200 μg). The control employed for this assay was serum from an adult mice immunized subcutaneously with 2KD1 (50 ng) in the presence of adjuvants. The panel below shows seric IgG Ab response against 2KD1/3B2 in adult mice immunized subcutaneously with 50 ng of VHH at PID 0 and 21 with or without adjuvants. For this experiment, four adult mice per group were used. The adjuvant employed was Freund’s complete adjuvant for the first immunization, while Freund´s incomplete adjuvant was used in the second one. Arrows indicates immunization time for both experiments.