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. 2016 Mar 8;5(3):e292. doi: 10.1038/mtna.2016.1

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Delivery of fluorescence-labeled pshRNA eye drops. (a) Left panel: bare siRNA with fluorescent label; right panel: fluorescence-labeled pshRNA enclosed in the lipid nanoparticle. The pshRNA was distributed only in the superficial layer of the corneal epithelium, while the Li-pshRNA was observed in almost all layers. (b) Delivery of fluorescence-labeled Li-pshRNA drops to mouse eyes. Samples were extracted at 1, 3, and 6 hours after instillation of the eye drops. Left panel: saline as control. Right panel: fluorescence-labeled Li-pshRNA. The Li-pshRNA was distributed to all layers as time advanced. Epi, epithelium; Endo, endothelium of cornea; St, stroma. Li-pshRNA, proline-modified short hairpin RNA wrapped with liposome.