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. 2016 Mar 8;5(3):e292. doi: 10.1038/mtna.2016.1

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Inhibition of ANGPTL2 mRNA by ANGPTL2 Li-pshRNA eye drops after chemical injury. (a) Fluorescence-labeled topical ANGPTL2 Li-pshRNA permeated the entire thickness of the injured cornea at 1 and 3 hours after injury. (b) ANGPTL2 mRNA expression was reduced after topical administration of ANGPTL2 Li-pshRNA eye drops 36 hours after injury (P = 0.017 and 0.032 for saline as control and negative Li-pshRNA, respectively; n = 6). ANGPTL2 mRNA expression was not inhibited by negative Li-pshRNA. *P < 0.05. (c) At 48 hours after injury, levels of ANGPTL2 expression were the same among all three groups. ANGPTL2, angiopoietin-like protein 2; Li-pshRNA, proline-modified short hairpin RNA wrapped with liposome.