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Assessment of overall similarity using a least squares model. (A) Calculation of z-score for each sequence in each distribution (blue dotted line) and the delta z relative to wild type (red dotted line), Figs 2–6. (B) Plots of Hamming distance versus Least Squares Distance, D, for 1,000 permuted sequences generated from each of the four permutation scripts, indicated in top left of each panel. The Hamming distance is in nucleotides across the 2,643 base capsid sequence of poliovirus.
