Table 4.
The homolog gene clusters identified by multiple pairwise comparisons. Genes of different species were mapped to homolog cluster for summarization across comparisons. Top 2% genes with the most significant p values were selected from each comparison. Poisson test (λ = 0.02) was performed on each gene cluster to identify those gene clusters more likely to be included in the top 2% lists. This table listed the most significant clusters identified by at least 5 independent data sets generated from at least 3 species.
| Homolog ID |
Human Gene |
Human Symbol |
Num Totala |
Num Comparisonb |
Num Datasetb |
Num Speciesb |
p Poisson |
FDR Poisson |
|---|---|---|---|---|---|---|---|---|
| 8622 | 23474 | ETHE1 | 60 | 12 | 7 | 4 | 6.17E-09 | 6.31E-05 |
| 55759 | 8140 | SLC7A5 | 52 | 11 | 5 | 3 | 1.49E-08 | 9.21E-05 |
| 3343 | 4716 | NDUFB10 | 52 | 9 | 6 | 3 | 1.55E-06 | 4.51E-03 |
| 1547 | 2617 | GARS | 60 | 9 | 5 | 3 | 4.86E-06 | 6.72E-03 |
| 2255 | 6390 | SDHB | 60 | 9 | 7 | 3 | 4.86E-06 | 6.72E-03 |
| 37514 | 513 | ATP5D | 60 | 9 | 7 | 4 | 4.86E-06 | 6.72E-03 |
| 4788 | 10667 | FARS2 | 55 | 8 | 5 | 3 | 2.01E-05 | 1.21E-02 |
| 68163 | 290 | ANPEP | 55 | 8 | 5 | 3 | 2.01E-05 | 1.21E-02 |
| 3 | 34 | ACADM | 60 | 8 | 6 | 3 | 3.70E-05 | 1.68E-02 |
| 3356 | 5106 | PCK2 | 60 | 8 | 6 | 3 | 3.70E-05 | 1.68E-02 |
| 457 | 6609 | SMPD1 | 60 | 8 | 5 | 3 | 3.70E-05 | 1.68E-02 |
| 55662 | 4967 | OGDH | 60 | 8 | 7 | 3 | 3.70E-05 | 1.68E-02 |
| 10884 | 4729 | NDUFV2 | 45 | 7 | 5 | 3 | 4.34E-05 | 1.93E-02 |
a
The total number of comparisons that included this gene cluster;
b
Num_Comparison, Num_Dataset, and Num_Species: the number of comparisons, data sets, and species that identified this cluster within the top 2% lists