Table 7.
Sample of the enrichment analysis results. Enrichment analysis results for the highest human dataset MSRx bicluster, bicluster 3, using DAVID tools.
| Categorya | Termb | Genesc | %d | P–Value | Fisher Exact |
|---|---|---|---|---|---|
| SP_PIR_KEYWORDS | respiratory chain | NDUFA9, COX8A, UQCRQ, COX5B |
80 | 1.90E-07 | 8.50E-10 |
| GOTERM_CC_FAT | mitochondrial inner membrane | NDUFA9, SUCLG1, COX8A, UQCRQ, COX5B |
100 | 3.20E-07 | 7.60E-09 |
| GOTERM_CC_FAT | organelle inner membrane | NDUFA9, SUCLG1, COX8A, UQCRQ, COX5B |
100 | 4.30E-07 | 1.10E-08 |
| GOTERM_CC_FAT | mitochondrial membrane | NDUFA9, SUCLG1, COX8A, UQCRQ, COX5B |
100 | 8.90E-07 | 2.70E-08 |
| GOTERM_CC_FAT | mitochondrial envelope | NDUFA9, SUCLG1, COX8A, UQCRQ, COX5B |
100 | 1.10E-06 | 3.70E-08 |
| SP_PIR_KEYWORDS | mitochondrion | NDUFA9, SUCLG1, COX8A, UQCRQ, COX5B |
100 | 3.50E-06 | 1.50E-07 |
| GOTERM_CC_FAT | mitochondrial part | NDUFA9, SUCLG1, COX8A, UQCRQ, COX5B |
100 | 4.70E-06 | 2.20E-07 |
| GOTERM_CC_FAT | organelle envelope | NDUFA9, SUCLG1, COX8A, UQCRQ, COX5B |
100 | 5.50E-06 | 2.60E-07 |
| GOTERM_CC_FAT | envelope | NDUFA9, SUCLG1, COX8A, UQCRQ, COX5B |
100 | 5.60E-06 | 2.70E-07 |
| GOTERM_BP_FAT | generation of precursor metabo- lites and energy |
NDUFA9, SUCLG1, COX8A, UQCRQ |
80 | 4.80E-05 | 1.40E-06 |
| GOTERM_CC_FAT | mitochondrion | NDUFA9, SUCLG1, COX8A, UQCRQ, COX5B |
100 | 5.20E-05 | 4.40E-06 |
| GOTERM_CC_FAT | organelle membrane | NDUFA9, SUCLG1, COX8A, UQCRQ, COX5B |
100 | 5.40E-05 | 4.60E-06 |
| UP_SEQ_FEATURE | transit peptide:Mitochondrion | NDUFA9, SUCLG1, COX8A, COX5B |
80 | 5.70E-05 | 1.70E-06 |
| SP_PIR_KEYWORDS | transit peptide | NDUFA9, SUCLG1, COX8A, COX5B |
80 | 5.90E-05 | 1.80E-06 |
| KEGG_PATHWAY | Parkinson’s disease | NDUFA9, COX8A, UQCRQ, COX5B |
80 | 6.10E-05 | 1.90E-06 |
| KEGG_PATHWAY | Oxidative phosphorylation | NDUFA9, COX8A, UQCRQ, COX5B |
80 | 6.40E-05 | 2.00E-06 |
| KEGG_PATHWAY | Alzheimer’s disease | NDUFA9, COX8A, UQCRQ, COX5B |
80 | 1.30E-04 | 5.00E-06 |
| KEGG_PATHWAY | Huntington’s disease | NDUFA9, COX8A, UQCRQ, COX5B |
80 | 1.70E-04 | 7.40E-06 |
| GOTERM_MF_FAT | hydrogen ion transmembrane transporter activity |
COX8A, UQCRQ, COX5B |
60 | 2.80E-04 | 3.20E-06 |
| GOTERM_MF_FAT | monovalent inorganic cation trans- membrane transporter activity |
COX8A, UQCRQ, COX5B |
60 | 3.80E-04 | 4.90E-06 |
| SP_PIR_KEYWORDS | mitochondrion inner membrane | COX8A, UQCRQ, COX5B |
60 | 5.90E-04 | 9.80E-06 |
| GOTERM_MF_FAT | inorganic cation transmembrane transporter activity |
COX8A, UQCRQ, COX5B |
60 | 7.90E-04 | 1.50E-05 |
| KEGG_PATHWAY | Cardiac muscle contraction | COX8A, UQCRQ, COX5B |
60 | 1.40E-03 | 3.40E-05 |
| SP_PIR_KEYWORDS | mitochondrial inner membrane | COX8A, COX5B | 40 | 3.90E-03 | 9.20E-06 |
| SP_PIR_KEYWORDS | oxidoreductase | NDUFA9, COX8A, COX5B |
60 | 4.90E-03 | 2.40E-04 |
| SP_PIR_KEYWORDS | membrane-associated complex | COX8A, COX5B | 40 | 6.60E-03 | 2.70E-05 |
| SP_PIR_KEYWORDS | oxidative phosphorylation | COX8A, COX5B | 40 | 7.30E-03 | 3.20E-05 |
| GOTERM_MF_FAT | oxidoreductase activity, acting on heme group of donors |
COX8A, COX5B | 40 | 8.60E-03 | 4.50E-05 |
| GOTERM_MF_FAT | cytochrome-c oxidase activity | COX8A, COX5B | 40 | 8.60E-03 | 4.50E-05 |
| GOTERM_MF_FAT | heme-copper terminal oxidase activity | COX8A, COX5B | 40 | 8.60E-03 | 4.50E-05 |
| GOTERM_MF_FAT | oxidoreductase activity, acting on heme group of donors, oxygen as acceptor |
COX8A, COX5B | 40 | 8.60E-03 | 4.50E-05 |
| SP_PIR_KEYWORDS | electron transfer | COX8A, COX5B | 40 | 1.00E-02 | 6.60E-05 |
| SP_PIR_KEYWORDS | electron transport | NDUFA9, UQCRQ | 40 | 2.10E-02 | 2.60E-04 |
| GOTERM_CC_FAT | respiratory chain | NDUFA9, UQCRQ | 40 | 2.30E-02 | 3.40E-04 |
| GOTERM_BP_FAT | cellular respiration | NDUFA9, SUCLG1 | 40 | 2.80E-02 | 5.00E-04 |
| GOTERM_BP_FAT | electron transport chain | NDUFA9, UQCRQ | 40 | 3.30E-02 | 6.90E-04 |
| INTERPRO | NAD(P)-binding domain | NDUFA9, SUCLG1 | 40 | 3.60E-02 | 7.90E-04 |
| UP_SEQ_FEATURE | cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
SUCLG1, UQCRQ | 40 | 4.10E-02 | 1.10E-03 |
| GOTERM_BP_FAT | energy derivation by oxidation of organic compounds |
NDUFA9, SUCLG1 | 40 | 4.20E-02 | 1.10E-03 |
| SP_PIR_KEYWORDS | isopeptide bond | SUCLG1, UQCRQ | 40 | 6.50E-02 | 2.70E-03 |
| GOTERM_CC_FAT | mitochondrial lumen | NDUFA9, SUCLG1 | 40 | 6.90E-02 | 3.00E-03 |
| GOTERM_CC_FAT | mitochondrial matrix | NDUFA9, SUCLG1 | 40 | 6.90E-02 | 3.00E-03 |
| SP_PIR_KEYWORDS | acetylation | NDUFA9, SUCLG1, COX5B |
60 | 9.30E-02 | 2.10E-02 |
a
The original source (i.e., database) of the term.
b
The enrichment terms associated with the gene list.
c
The list of genes from the bicluster that is involved in the term.
d
The percentage of the bicluster genes that involved in this term (Involved genes/total genes).