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. 2015 Dec 1;4(12):e265. doi: 10.1038/mtna.2015.40

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Copyright © 2015 Official journal of the American Society of Gene & Cell Therapy

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Kidneys demonstrate high basal CD40 expression, which is highly upregulated within the cortical interstitium following CD40 activation. (a) A comparison of whole organ CD40 protein measured by enzyme-linked immunosorbent assay in healthy, inflammation-naive C57BL/6 mice. (b) CD40 and CD40-dependent inflammation measured by quantitative real-time polymerase chain reaction in the kidney 24 hours following IV administration of an activating CD40 mAb in wild-type or CD40-deficient mice. Data are normalized to mice not receiving the Ab. Renal cortex and medulla CD40 in situ hybridization (ISH) (c,d) and CCL5 ISH (e) before administration of the CD40 mAb (c) or 24 hours following the CD40 mAb (d,e). Mean ± SEM, n = 4/group, scale bar = 50 μm, *P < 0.05 versus all tissues (a) or versus no Ab control (b).