Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Dec 1;4(12):e265. doi: 10.1038/mtna.2015.40

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

CD40 ASO treatment mitigated DOX nephropathy. CD40 antisense oligonucleotide (ASO) and control ASO treatments were initiated 2 weeks following initiation of DOX nephropathy and after 8 weeks of ASO treatments renal functional assessments of (a) proteinuria (graphed as the ratio of the urine albumin to creatinine) and (b) plasma fluorescein isothicyanate conjugated inulin (FITC)-inulin elimination (assessed by a single measurement of residual plasma FITC-Inulin two hours following FITC-inulin injection) were performed. Additionally, kidneys were harvested and whole kidney (c) CD40 mRNA and protein, (d) CCL5, MCP-1 and NGAL mRNA, and (e) CCL5 protein were measured. (f–i) Periodic acid-Schiff staining of representative kidney sections from (f) phosphate buffered saline (PBS), (g) control ASO, (h) 12.5 mg/kg CD40 ASO, and (i) 25 mg/kg CD40 ASO groups. Mean ± SEM, *P < 0.05 versus Dox PBS group, n = 10–12/group (DOX mice) or 6/group (healthy control mice), scale bar = 50 μm.