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. Author manuscript; available in PMC: 2016 Dec 27.
Published in final edited form as: Nat Nanotechnol. 2016 Jun 27;11(9):776–782. doi: 10.1038/nnano.2016.96

Figure 2. AP evolution during tissue development.

Figure 2

(a) Amplitudes of spontaneous extracellular APs recorded from 4 × 6 nanowire FET arrays in two layers at 2, 4, 6 and 8 DIV. White squares correspond to coordinates where extracellular APs are absent or below the detection limit (1× standard deviation of noise level). Time-dependent data recorded from four devices (2 × L1 and 2 × L2) indicated with asterisks at 2 DIV are shown in Supplementary Fig. 5. (b) Histogram of extracellular AP amplitudes recorded from the 3D nanoelectronics-cardiac tissue sample at 2, 4, 6 and 8 DIV.