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. Author manuscript; available in PMC: 2017 Sep 3.
Published in final edited form as: Lancet. 2016 Jul 22;388(10048):983–993. doi: 10.1016/S0140-6736(16)30826-1

Figure 3. Survival analysis of time to allograft loss.

Figure 3

(A) Kaplan-Meier plot of time to allograft loss for patients stratified into high-risk and low-risk groups according to the gene set risk score, which was calculated by the linear combination of eigenvalues of significant principle components multiplied by their coefficiencies in a Cox proportional hazard model. Hazard ratio of graft loss was estimated from the coefficiency of the gene risk score in the Cox proportional model. (B) ROC curves for prediction of allograft loss within 2 years or 3 years after the 3-month biopsy. (C) Kaplan-Meier plot of time to allograft loss for patients from a publically available dataset (GSE21374)10 who were stratified into high-risk and low-risk groups according to the gene set risk score. (D) ROC curves for prediction of time to allograft loss by 1 year and 2 years post-biopsy through application of the gene set risk score to the publically available dataset.10 AUC=area under the curve. ROC=receiver operating characteristic. HR=hazard ratio.