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. Author manuscript; available in PMC: 2016 Sep 7.
Published in final edited form as: J Allergy Clin Immunol. 2016 Jul 20;138(3):700–710. doi: 10.1016/j.jaci.2016.04.051

Figure 3. MRGPRX2 signaling in MCs.

Figure 3

The ligands for MRGPRX2 activate pertussis toxin-dependent Gαi and pertussis toxin-independent Gαq pathways for MC responses. MCs express MRGPRX2 on the cell surface as well as intracellular sites. The extracellular receptor probably uses the Orai-1 Ca2+ channel and the pertussis toxin-independent Gαq pathway for MC degranulation whereas the intracellular receptor may use the Orai-2 Ca2+ channel to mediate MC responses. Activation of MRGPRX2 also results in Gαi-dependent production of the pruritogenic cytokine IL-31 via the MAP kinase and Akt-dependent pathways.