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(A) Overlaid structures of DK17 bound to GM1 (Purple), POPC:POPG:Cholesterol:GM1 (Cyan), and TLBE (Green) LUVs. The central helical segment (Ile6-Arg11) seems to be superimposed nicely with a conserved helical propensity. (B) The Ile6-Phe8 motif is highlighted in the overlaid structures of DK17 in different LUVs.
