. Author manuscript; available in PMC: 2017 Oct 1.

Published in final edited form as: Bioorg Med Chem. 2016 Aug 6;24(19):4692–4700. doi: 10.1016/j.bmc.2016.08.006

Table 3.

The Effect of Linker Length of Curcumin Mimics on Anti-Proliferative Activity

Compd.	Linker	IC₅₀(curcumin)/IC₅₀(curcumin mimic)			Note
Compd.	Linker	PC-3	DU145	LNCaP	Note
3 ^a	5-carbon	111	50	30	The optimal candidate for the series
4 ^a	5-carbon	82	90	57
5 ^b	7-carbon	36	29	11	The optimal candidate for the series
6 ^b	7-carbon	14	25	11
82	9-carbon	10	8	4.5
69	9-carbon	10	15	2
78	9-carbon	23	22	14	The optimal candidate for the series

Data from ref. 19;

Data from ref. 20.